df.resample("5T").mean()
Out[8]:
OPEN HIGH LOW CLOSE VOLUME
DATE_TIME
1997-02-03 09:00:00 3046.0 3048.5 3046.0 3047.5 505.0
1997-02-03 09:05:00 3047.6 3047.9 3046.8 3047.3 159.6
1997-02-03 09:10:00 3045.6 3045.9 3044.8 3045.0 110.2
1997-02-03 09:15:00 3043.6 3044.0 3042.8 3043.2 69.2
1997-02-03 09:20:00 3044.7 3045.2 3044.5 3045.0 65.8
1997-02-03 09:25:00 3043.8 3044.0 3043.5 3043.7 59.0
1997-02-03 09:30:00 3044.6 3045.0 3044.3 3044.6 56.0
1997-02-03 09:35:00 3044.5 3044.5 3043.5 3044.5 44.0