import csv
with open(fpath, 'r') as infile:
reader = csv.DictReader(infile)
fieldnames = reader.fieldnames
In [27]: df
Out[27]:
A B C
0 -0.166919 0.979728 -0.632955
1 -0.297953 -0.912674 -1.365463
2 -0.120211 -0.540679 -0.680481
In [28]: df.columns
Out[28]: Index (['A', 'B', 'C'], dtype='object')