User.objects.filter(first_name__contains='John', last_name__contains='Smith')
or
User.objects.filter(first_name__contains='J', last_name__contains='h')
Entity.objects.filter(
Q(first_name__istartswith="Firstname") | Q(last_name__istartswith="Firstname") |
Q(first_name__istartswith="Lastname") | Q(last_name__istartswith="Lastname")
)