If you want to remove specific punctuation from a string, it will probably be best to explicitly remove exactly what you want like
replace(/[.,/#!$%^&*;:{}=-_`~()]/g,"")
Doing the above still doesn't return the string as you have specified it. If you want to remove any extra spaces that were left over from removing crazy punctuation, then you are going to want to do something like
replace(/s{2,}/g," ");