In [1]: df = pd.DataFrame({'A': [5,6,3,4], 'B': [1,2,3,5]}) In [2]: df Out[2]: A B 0 5 1 1 6 2 2 3 3 3 4 5 In [3]: df[df['A'].isin([3, 6])] Out[3]: A B 1 6 2 2 3 3