import xlwt
import xlrd
from xlutils.copy import copy
# load the excel file
rb = xlrd.open_workbook('UserBook.xls')
# copy the contents of excel file
wb = copy(rb)
# open the first sheet
w_sheet = wb.get_sheet(0)
# row number = 0 , column number = 1
w_sheet.write(0,1,'Modified !')
# save the file
wb.save('UserBook.xls')