In [1]: df = pd.read_csv('foo.csv', index_col=0)
In [2]: df
Out[2]:
A B C
0 1 2 3
1 4 5 6
In [3]: df + 6
Out[3]:
A B C
0 7 8 9
1 10 11 12
In [4]: with open('foo.csv', 'a') as f:
(df + 6).to_csv(f, header=False)