import datetime, xlrd book = xlrd.open_workbook("myexcelfile.xls") sh = book.sheet_by_index(0) a1 = sh.cell_value(rowx=0, colx=0) a1_as_datetime = datetime.datetime(*xlrd.xldate_as_tuple(a1, book.datemode)) print 'datetime: %s' % a1_as_datetime