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import win32com.client

xlApp = win32com.client.Dispatch("Excel.Application")
xlApp.Visible=1

workBook = xlApp.Workbooks.Open(r"C:MyTest.xls")
print str(workBook.ActiveSheet.Cells(i,1))
workBook.ActiveSheet.Cells(1, 1).Value = "hello"                
workBook.Close(SaveChanges=0) 
xlApp.Quit()

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