PYTHON

self.app = Tk()

# Use Tkinter for python 2, tkinter for python 3
import tkinter as tk

class MainApplication(tk.Frame):
    def __init__(self, parent, *args, **kwargs):
        tk.Frame.__init__(self, parent, *args, **kwargs)
        self.parent = parent

        <create the rest of your GUI here>

if __name__ == "__main__":
    root = tk.Tk()
    MainApplication(root).pack(side="top", fill="both", expand=True)
    root.mainloop()