>>> import numpy as np
>>> a1 = np.array([[1,2,3],[4,5,6],[7,8,9]])
>>> a2 = np.array([[4,5,6],[7,8,9],[1,1,1]])
>>> a1_rows = a1.view([('', a1.dtype)] * a1.shape[1])
>>> a2_rows = a2.view([('', a2.dtype)] * a2.shape[1])
>>> np.setdiff1d(a1_rows, a2_rows).view(a1.dtype).reshape(-1, a1.shape[1])
array([[1, 2, 3]])